期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 87, 期 -, 页码 125-144出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.04.003
关键词
Planaria; Dugesia japonica; Regeneration; Patterning; Morphostasis
资金
- Allen Discovery Center award from The Paul G. Allen Frontiers Group [12171]
- National Institutes of Health [AR055993, AR061988]
- G. Harold and Leila Y. Mathers Charitable Foundation [TFU141]
- National Science Foundation [CBET-0939511]
- W. M. KECK Foundation [5903]
- Templeton World Charity Foundation [TWCF0089/AB55]
Planarian behavior, physiology, and pattern control offer profound lessons for regenerative medicine, evolutionary biology, morphogenetic engineering, robotics, and unconventional computation. Despite recent advances in the molecular genetics of stem cell differentiation, this model organism's remarkable anatomical homeostasis provokes us with truly fundamental puzzles about the origin of large-scale shape and its relationship to the genome. In this review article, we first highlight several deep mysteries about planarian regeneration in the context of the current paradigm in this field. We then review recent progress in understanding of the physiological control of an endogenous, bioelectric pattern memory that guides regeneration, and how modulating this memory can permanently alter the flatworm's target morphology. Finally, we focus on computational approaches that complement reductive pathway analysis with synthetic, systems-level understanding of morphological decision-making. We analyze existing models of planarian pattern control and highlight recent successes and remaining knowledge gaps in this interdisciplinary frontier field. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据