期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 85, 期 -, 页码 3-12出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.12.010
关键词
Axon guidance; Commissural axon; Midline crossing; Guidance signaling; Repulsion; Attraction; Growth cone
资金
- LABEX CORTEX
- DEVWECAN of the Universite de Lyon, within the programme 'Investissements d'Avenir' [ANR-11-IDEX-0007, ANR-16-CE16-0023-01]
- French Muscular Dystrophy Association (AFM)
- Agence Nationale de la Recherche (ANR) [ANR-16-CE16-0023] Funding Source: Agence Nationale de la Recherche (ANR)
The navigation of commissural axons in the developing spinal cord has attracted multiple studies over the years. Many important concepts emerged from these studies which have enlighten the general mechanisms of axon guidance. The navigation of commissural axons is regulated by a series of cellular territories which provides the diverse guidance information necessary to ensure the successive steps of their pathfinding towards, across, and away from the ventral midline. In this review, we discuss how repulsive forces, by propelling, channelling, and confining commissural axon navigation, bring key contributions to the formation of this neuronal projection. (C) 2017 Elsevier Ltd. All rights reserved.
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