期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 77, 期 -, 页码 133-143出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.10.016
关键词
Genetics; Gene-Environment interaction; Diathesis-Stress; Differential; Susceptibility; Psychiatry
资金
- Medical Research Council [MR/K021281/2, MR/K021281/1] Funding Source: Medline
- MRC [MR/K021281/1, MR/K021281/2] Funding Source: UKRI
- Medical Research Council [MR/K021281/1, MR/K021281/2] Funding Source: researchfish
Empirical studies suggest that psychiatric disorders result from a complex interplay between genetic and environmental factors. Most evidence for such gene-environment interaction (GxE) is based on single candidate gene studies conducted from a Diathesis-Stress perspective. Recognizing the short-comings of candidate gene studies, GxE research has begun to focus on genome-wide and polygenic approaches as well as drawing on different theoretical concepts underlying GxE, such as Differential Susceptibility. After reviewing evidence from candidate GxE studies and presenting alternative theoretical frameworks underpinning GxE research, more recent approaches and findings from whole genome approaches are presented. Finally, we suggest how future GxE studies may unpick the complex interplay between genes and environments in psychiatric disorders. (C) 2017 Elsevier Ltd. All rights reserved.
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