期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 625, 期 -, 页码 566-574出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2017.12.186
关键词
Perfluoroalkyl substances; Perfluorooctanoate; Diabetes; Metabolites; Total cholesterol
资金
- National Natural Science Foundation of China [81370920, 81770773]
- Natural Science Foundation of Jiangsu Province [BK20171499]
- Project of Six Talents Peak of Jiangsu Province [2013WSN-023]
- Jiangsu Province's Key Medical Talents (co-construction) Program
- Project of 333 Talent in Jiangsu Province
- Jiangsu Province Official Hospital Scientific Research Initial Funding [RPF201501]
- Jiangsu Province Official Hospital Talents Construction Fund Research Project [IR2015101]
Exposure to perfluoroalkyl substances (PFAS) is associated with a range of adverse health effects. However, it remains unclear whether PFAS at environmentally relevant exposure levels are related to diabetes and metabolite concentrations in adults. Using cross-sectional data from 7904 adults (age >= 20 years) in the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we examined the association of PFAS with the prevalence of diabetes and metabolite concentrations. A multivariate logistic regression was applied to investigate the associations of diabetes prevalence with serum perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS) and perfluorononanoate (PFNA) levels. A multivariate generalised linear regression was further performed to investigate the associations between PFAS exposure and some metabolites. We identified a strong positive association between serum PFOA and diabetes prevalence in men with an adjusted model (OR: 2.66, 95% CI: 1.63-4.35; P for trend = 0.001). No significant association between serum PFOA and diabetes prevalence was observed in women (OR: 1.47, 95% CI: 0.88-2.46; P for trend = 0.737). Furthermore, diabetes was not related to PFOS, PFHxS and PFNA, regardless of gender. In the gender-stratified generalised linear models, men and women with the highest PFOA levels demonstrated a 1.43% (95% CI: 0.62%-2.34%) and a 1.07% (95% CI: 0.27%-1.97%) greater increase in serumtotal cholesterol (P for trend= 0.006 and 0.001) compared to those with the lowest PFOA levels. There were no significant associations between serum PFOA and other metabolites. These results provide epidemiological evidence that environment-related levels of serum PFOA may be positively associated with the prevalence of diabetes in men and with total cholesterol in adults. Further clinical and animal studies are urgently needed to elucidate putative causal relationships and shed light on the potential mode of action involved. (C) 2017 Published by Elsevier B.V.
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