期刊
PHYSIOLOGICAL RESEARCH
卷 61, 期 6, 页码 655-658出版社
ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
DOI: 10.33549/physiolres.932333
关键词
Catalase; Polymorphism; Free radicals; H2O2
类别
Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C > T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H2O2-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H2O2. Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.
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