期刊
SCIENCE CHINA-LIFE SCIENCES
卷 61, 期 12, 页码 1554-1565出版社
SCIENCE PRESS
DOI: 10.1007/s11427-017-9272-2
关键词
premature ovarian failure; collagen scaffold; UC-MSCs; primordial follicle activation; granulosa cells; FOXO3a; FOXO1
类别
资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01030501]
- National Natural Science Foundation of China [31571189, 81571391, 30900847]
- Nanjing Medical Science Development Project [JQX14004, ZKX16042]
- [QNRC2016006]
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.
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