期刊
SCIENCE CHINA-CHEMISTRY
卷 61, 期 7, 页码 806-811出版社
SCIENCE PRESS
DOI: 10.1007/s11426-017-9217-4
关键词
mesoporous silica nanoparticles; magnetic resonance imaging; pH-response; cancer diagnosis; cancer therapy
资金
- National Natural Science Foundation of China [81501461, 21635002]
- Open Research Fund for Expensive Instrument Testing of Fuzhou University [2017T026, 2017T028]
The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and sensitivity. In this work, we report a pH-responsive theranostic nanoplatform based on FeOOH clusters loaded mesoporous silica nanoparticles (Fe@MSNs). The as-synthesized Fe@MSNs possess activatable T (1) magnetic resonance imaging (MRI) performance that can respond to the acidic microenvironment of solid tumor to turn on T (1) singals by releasing paramagnetic Fe3+ ions. The Fe@MSNs are biocompatible without appreciable cytotoxicity. Moreover, the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid tumor. We believe that this novel pH-responsive theranostic nanoplatform holds great promise in cancer treatment.
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