期刊
SCIENCE
卷 360, 期 6391, 页码 915-918出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aas9315
关键词
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资金
- Texas Instruments
- Hong Kong Innovation and Technology Fund [ITS/195/14FP]
- Office of Naval Research [N00014-13-1-0424]
- NSF Biological Computing [1522074]
- Center for Microbiome Informatics and Therapeutics [15127713]
- Division of Gastroenterology, Brigham and Women's Hospital
- NIH [EB-000244]
- Qualcomm Innovation Fellowship
- HHMI International Student Fellowship
- Natural Sciences and Engineering Council of Canada Fellowship
Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.
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