期刊
SCIENCE
卷 359, 期 6373, 页码 314-319出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aao3466
关键词
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资金
- Engineering and Physical Sciences Research Council [EP/H024107/1, EP/J015156/1, EP/K021966/1, EP/L015668/1, EP/L023652/1]
- European Research Council [670467 SMART-POM]
- Defense Advanced Research Projects Agency (DARPA)
- EPSRC [EP/R01308X/1, EP/L023652/1, EP/L015668/1, EP/J015156/1, EP/K021966/1, EP/H024107/1] Funding Source: UKRI
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the g-aminobutyric acid receptor agonist, (+/-)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.
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