期刊
SCIENCE
卷 360, 期 6391, 页码 881-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aar4237
关键词
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资金
- Max Planck Society
- European Research Council under the European Union/ERC [322705]
- European Research Council (ERC) [322705] Funding Source: European Research Council (ERC)
Computations in the mammalian cortex are carried out by glutamatergic and gamma-aminobutyric acid-releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.
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