期刊
SCIENCE
卷 359, 期 6376, 页码 658-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aao5056
关键词
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资金
- European Research Council
- Swiss National Science Foundation [BSCGI0_157859]
- Zurich Neuroscience Center
- Wellcome Trust [098357/Z/12/Z]
- European Molecular Biology Organization Long-Term Fellowship
- SystemsX transition postdoctoral fellowship
- Swiss National Science Foundation (SNF) [BSCGI0_157859] Funding Source: Swiss National Science Foundation (SNF)
- Wellcome Trust [098357/Z/12/Z] Funding Source: Wellcome Trust
Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis.
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