期刊
SCHIZOPHRENIA BULLETIN
卷 45, 期 3, 页码 579-590出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sby094
关键词
psychosis; first episode; dysconnectivity; connectivity; functional connectivity; networks
类别
资金
- Medical Research Council (MRC), UK [MR/J012149/1, MC_ PC_14105 v.2]
- National Institute for Health Research (NIHR) (NIHR Clinician Scientist Award) [NIHR CS-11-001]
- NIHR Mental Health Biomedical Research Centre at South London and Maudsley National Health Service (NHS) Foundation Trust and King's College London
- NIHR Collaboration for Leadership in Applied Health Research and Care South London, at King's College Hospital NHS Foundation Trust
- MRC [MR/J012149/1, MC_PC_14105] Funding Source: UKRI
Objective: Increasingly, studies have identified abnormalities in the functional connectivity (FC) of large-scale neural networks in early psychosis, but the findings thus far have been inconclusive. Therefore, the aim of this study was to identify robust alterations in FC of the default mode (DMN), salience (SN), and central executive networks (CEN), in patients with first-episode psychosis (FEP) using a meta-analytic approach. Methods: Included studies were required to be resting-state, seed-to-whole brain, FC neuroimaging studies, comparing FEP patients to healthy controls (HC), with seeds within the boundaries of the region-of-interest networks. Peak effect coordinates and peak t, z, or p values were meta-analyzed using Seed-based d Mapping software. Results: The DMN seeds primarily displayed within-network hypoconnectivity (largest clusters including the middle orbital gyrus; and ventral anterior cingulate gyrus). The SN seeds displayed hypoconnectivity with regions in the DMN and CEN (largest clusters located in the bilateral middle temporal gyri). Review of the limited CEN data revealed hypo- and hyperconnectivity across the networks. Negative symptoms were positively correlated with all DMN FC abnormalities in the FEP group. Antipsychotic-treated patients displayed greater hypoconnectivity than antipsychotic-nave patients between both the DMN/SN seeds and prefrontal regions. Conclusions: These findings provide substantial evidence of widespread resting-state FC abnormalities of the DMN, SN, and CEN in early psychosis; particularly implicating DMN and SN dysconnectivity as a core deficit underlying the psychopathology of psychosis. Additionally, we highlight the importance of disentangling connectivity abnormalities resulting from disease processes, from those that result from antipsychotic treatment.
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