Metallomicellar Complex of 1-Hexadecyl-4-aza-1-azoniabicyclo-[2.2.2]octane Bromide with Copper Dibromide for Solubilization of Nitrofurantoin

Associates of amphiphilic 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide-copper dibromide complex solubilize nitrofurantoin (furadonin). The solubilizing capacity of premicellar aggregates with respect to nitrofurantoin is 15 times higher than that of micelles and is considerably higher (by a factor of 5-16) than the solubilizing effect of micellar solutions of the complex, ligand, and conventional cationic surfactants with respect to Orange OT.