期刊
RNA
卷 24, 期 8, 页码 1005-1017出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.065565.118
关键词
microRNA; Gene Ontology; functional annotation; bioinformatic resource; network analysis; pathway analysis
资金
- British Heart Foundation Programme grant [RG/13/5/30112]
- Fondation Leducq (MIRVAD) [13 CVD 02]
- National Institute for Health Research Biomedical Research Center based at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London
- King's College Hospital
- British Heart Foundation
- National Institute for Health Research Biomedical Research Centre Cardiometabolic Programme, University College London Hospitals [BRC105CMSH/5982]
- European Molecular Biology Laboratory core funds
MicroRNA regulation of key biological and developmental pathways is a rapidly expanding area of research, accompanied by vast amounts of experimental data. This data, however, is not widely available in bioinformatic resources, making it difficult for researchers to find and analyze microRNA-related experimental data and define further research projects. We are addressing this problem by providing two new bioinformatics data sets that contain experimentally verified functional information for mammalian microRNAs involved in cardiovascular-relevant, and other, processes. To date, our resource provides over 4400 Gene Ontology annotations associated with over 500 microRNAs from human, mouse, and rat and over 2400 experimentally validated microRNA: target interactions. We illustrate how this resource can be used to create microRNA-focused interaction networks with a biological context using the known biological role of microRNAs and the mRNAs they regulate, enabling discovery of associations between gene products, biological pathways and, ultimately, diseases. This data will be crucial in advancing the field of microRNA bioinformatics and will establish consistent data sets for reproducible functional analysis of microRNAs across all biological research areas.
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