期刊
RNA
卷 24, 期 4, 页码 585-596出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.064931.117
关键词
transcriptomics; RNA-seq; alternative splicing; brain development
资金
- National Natural Science Foundation of China [31420103920, 91331203]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13010200]
- China National One Thousand Foreign Experts Plan [WQ20123100078]
- Bureau of International Cooperation
- Chinese Academy of Sciences [GJHZ201313]
- Russian Science Foundation [16-14-00220, 1450-00150]
- Russian Science Foundation [16-14-00220] Funding Source: Russian Science Foundation
Changes in splicing are known to affect the function and regulation of genes. We analyzed splicing events that take place during the postnatal development of the prefrontal cortex in humans, chimpanzees, and rhesus macaques based on data obtained from 168 individuals. Our study revealed that among the 38,822 quantified alternative exons, 15% are differentially spliced among species, and more than 6% splice differently at different ages. Mutations in splicing acceptor and/or donor sites might explain more than 14% of all splicing differences among species and up to 64% of high-amplitude differences. A reconstructed trans-regulatory network containing 21 RNA-binding proteins explains a further 4% of splicing variations within species. While most age-dependent splicing patterns are conserved among the three species, developmental changes in intron retention are substantially more pronounced in humans.
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