期刊
RNA BIOLOGY
卷 15, 期 7, 页码 886-891出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2018.1481695
关键词
Retrograde signaling; small RNA; stress response
资金
- LabEx Saclay Plant Sciences-SPS [ANR-10-LABX-0040-SPS]
- French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INSB-05]
- Deutsche Forschungsgemeinschaft [Kr1350/7, Kr1350/9]
- Narodowe Centrum Nauki [UMO-2016/23/B/NZ9/00862]
- Ministerstwo Nauki i Szkolnictwa Wyzszego, KNOW RNAResearch Centre in Poznan [01/KNOW2/2014]
In this article a novel mechanism of retrograde signaling by chloroplasts during stress is described. This mechanism involves the DNA/RNA binding protein WHIRLY1 as a regulator of microRNA levels. By virtue of its dual localization in chloroplasts and the nucleus of the same cell, WHIRLY1 was proposed as an excellent candidate coordinator of chloroplast function and nuclear gene expression. Comparison of wild-type and transgenic plants with an RNAi-mediated knockdown of WHIRLY1 showed, that the transgenic plants were unable to cope with continuous high light conditions. They were impaired in production of several microRNAs mediating post-transcriptional responses during stress. The results support a central role of WHIRLY1 in retrograde signaling and also underpin a so far underestimated role of microRNAs in this process.
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