期刊
RHEUMATOLOGY
卷 57, 期 -, 页码 22-33出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kex515
关键词
exercise; knee osteoarthritis; management; mechanism; pathophysiology; skeletal muscle
类别
资金
- Postgraduate Scholarship in Rheumatology from the University of Sydney
- National Health and Medical Research Council
- Sir Randal Heymanson Research Fellowship from the University of Melbourne
The role of skeletal muscle in the pathophysiology of knee OA is poorly understood. To date, the majority of literature has focused on the association of muscle strength with OA symptoms, disease onset and progression. However, deficits or improvements in skeletal muscle strength do not fully explain the mechanisms behind outcome measures in knee OA, such as pain, function and structural disease. This review aims to summarize components of skeletal muscle, providing a holistic view of skeletal muscle mechanisms that includes muscle function, quality and composition and their interactions. Similarly, the role of skeletal muscle in the management of knee OA will be discussed.
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