Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts

Cyperus rotundus L. (Suada, Sueda, family: Cyperaceae) is vastly spread in several world's subtropical and tropical regions. It had variable traditional uses and bioactivities. A new flavonol derivative: cyperaflavoside (myricetin 3,3',5'-trimethyl ether 7-O-beta-D-glucopyranoside) and five flavonoids: vitexin, orientin, cinaroside, quercetin 3-O-beta-D-glucopyranoside, and myrcetin 3-O-beta-D-glucopyranoside were separated from the methanolic extract of C. rotundus aerial parts. Their structures were verified based on IJV, IR, NMR (1D and 2D), HRESIMS, and comparison with literature. All metabolites were assessed for their 5-lipoxygenase inhibitory potential. All compounds possessed 5-lipoxygenase inhibitory potentials with IC(50)s 5.1, 4.5, 5.9, 4.0, 3.7, and 2.3 mu M, respectively, in comparison to indomethacin (IC50 0.98 mu M). These results supported the traditional uses of C. rotundus in treating inflammation and its related symptoms. (C) 2018 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.