期刊
RESPIRATION
卷 95, 期 6, 页码 433-440出版社
KARGER
DOI: 10.1159/000487711
关键词
Severe idiopathic pulmonary fibrosis; Therapy; Nintedanib; Pirfenidone
Background: Two therapeutic options are currently available for patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. To date, there is still insufficient data on the efficacy of these 2 agents in patients with more severe disease. objectives: This national, multicenter, retrospective real-life study was intended to determine the impact of nintedanib on the treatment of patients with severe IPF. Methods: All patients included had severe IPF and had to have at least 6 months of follow-up before and at least 6 months of follow-up after starting nintedanib. The aim of the study was to compare the decline in lung function before and after treatment. Patient survival after 6 months of therapy with nintedanib was assessed. Results: Forty-one patients with a forced vital capacity (FVC) <= 50% and/or a diffusing capacity of the lung for carbon monoxide (D-LCO) <= 35% predicted at the start of nintedanib treatment were enrolled. At the 6-month follow-up, the decline of Dim (both absolute and % predicted) was significantly reduced compared to the pretreatment period (absolute D-LCO at the -6-month, T-0, and +6-month time points (5.48, 4.50, and 5.03 mmol/min/kPa, respectively, p = 0.03; D-LCO% predicted was 32.73, 26.54, and 29.23%, respectively, p = 0.04). No significant beneficial effect was observed in the other functional parameters analyzed. The 1-year survival in this population was 79%, calculated from month 6 of therapy with nintedanib. Conclusions: This nationwide multicenter experience in patients with severe IPF shows that nintedanib slows down the rate of decline of absolute and % predicted D-LCO but does not have significant impact on FVC or other lung parameters. (C) 2018 S. Karger AG, Basel
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