期刊
BIOMEDICAL REPORTS
卷 1, 期 1, 页码 119-121出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2012.5
关键词
Citrullus colocynthis extracts; streptozotocin; glucose-stimulated insulin release; rat isolated pancreatic islets; glycemia
Citrullus colocynthis extracts improve glucose homeostasis in alloxan- or streptozotocin (STZ)-induced diabetic rats. Little is known, however, regarding the protective effect of these extracts against the beta-cytotoxic action of STZ. In the present study, an H2O-methanol extract was found to suppress the inhibition of glucose-stimulated insulin secretion by STZ in rat-isolated pancreatic islets. Similarly, when an aqueous extract from Citrullus colocynthis seeds was injected daily for 21 days prior to STZ administration, the perturbation of glucose homeostasis otherwise generated by the beta-cytotoxic agent was minimized in rats.
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