期刊
RADIOTHERAPY AND ONCOLOGY
卷 129, 期 3, 页码 441-448出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2018.07.007
关键词
Ultrasound; Real-time monitoring; DIBH; SBRT; Diaphragm motion; CBCT
资金
- Elekta AB, Sweden
Background and purpose: Craniocaudal motion during image-guided abdominal SBRT can be reduced by computer-controlled deep-inspiratory-breath-hold (DIBH). However, a residual motion can occur in the DIBH-phases which can only be detected with intrafractional real-time-monitoring. We assessed the intra-breath-hold residual motion of DIBH and compared residual motion of target structures during DIBH detected by ultrasound (US). US data were compared with residual motion of the diaphragm-dome (DD) detected in the DIBH-CBCT-projections. Patients and methods: US-based monitoring was performed with an experimental US-system simultaneously to DIBH-CBCT acquisition. A total of 706 DIBHs during SBRT-treatments of metastatic lesions (liver, spleen, adrenal) of various primaries were registered in 13 patients. Residual motion of the target structure was documented with US during each DIBH. Motion of the DD was determined by comparison to a reference phantom-scan taking the individual geometrical setting at a given projection angle into account. Residual motion data detected by US were correlated to those of the DD (DIBH-CBCT-projection). Results: US-based monitoring could be performed in all cases and was well tolerated by all patients. Additional time for daily US-based setup required 8 +/- 4 min. 385 DIBHs of 706 could be analyzed. In 59% of all DIBHs, residual motion was below 2 mm. In 36%, residual motion of 2-5 mm and in 4% of 5-8 mm was observed. Only 1% of all DIBHs and 0.16% of all readings revealed a residual motion of >8 mm during DIBH. For DIBHs with a residual motion over 2 mm, 137 of 156 CBCT-to-US curves had a parallel residual motion and showed a statistical correlation. Discussion and conclusion: Soft-tissue monitoring with ultrasound is a fast real-time method without additional radiation exposure. Computer-controlled DIBH has a residual motion of <5 mm in >95% which is in line with the published intra-breath-hold-precision. Larger intrafractional deviations can be avoided if the beam is stopped at an US-defined threshold. (C) 2018 Elsevier B.V. All rights reserved.
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