期刊
TRANSCRIPTION-AUSTIN
卷 4, 期 1, 页码 24-28出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.22600
关键词
BRCA1; breast cancer; transcription; epigenetic regulation; micro RNA; miR-155
资金
- Center for Cancer Research, National Cancer Institute Intramural Program of the US National Institutes of Health, Department of Health and Human Services
Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.
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