期刊
JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION
卷 3, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1186/1869-5760-3-47
关键词
Collagen cross linking; Infectious keratitis; UV-A; Corneal melting
资金
- Spanish Ministry of Economy and Competitiveness
- Instituto Carlos III, Red Tematica Investigacion Cooperativa en Salud Patologia ocular del envejecimiento, calidad visual y calidad de vida [RD12/0034/0003]
Background: Collagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. The aim of this study is to summarize the previously published data and evaluate the effectiveness of this treatment. Results: The search identified 12 articles. The number of eyes was 104. The infectious keratitis was associated with bacteria in 58 eyes (57%): Gram-positive bacteria in 44 (43%; 4 of which were infected with Mycobacterium (3.6%)) and Gram-negative bacteria in 14 eyes (13%), fungus in 13 eyes (12%), and Acanthamoeba in 7 eyes (7%). In 26 eyes (25%), the microbiological culture was negative or not performed. The mean time of re-epithelization after CXL was 20.7 +/- 28.1 days (minimum of 3, maximum of 145). Sixteen eyes underwent deep or lamellar keratoplasty. The pooled analysis suggested that CXL has a favorable effect on the block of corneal melting in 85% (95%; CI 0.77, 0.91) of eyes. Conclusion: Although randomized controlled trials are needed, the available evidence supports the use of CXL in the treatment of infectious keratitis.
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