期刊
FLUIDS AND BARRIERS OF THE CNS
卷 10, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/2045-8118-10-3
关键词
Blood-brain barrier; Mouse models; Endothelial cells; Neuro; vascular unit; Astrocytes; Pericytes; Central Nervous system
资金
- Program for Breakthrough Biomedical Research
- American Heart Association
The blood-brain barrier (BBB) is a complex physiological structure formed by the blood vessels of the central nervous system (CNS) that tightly regulates the movement of substances between the blood and the neural tissue. Recently, the generation and analysis of different genetic mouse models has allowed for greater understanding of BBB development, how the barrier is regulated during health, and its response to disease. Here we discuss: 1) Genetic mouse models that have been used to study the BBB, 2) Available mouse genetic tools that can aid in the study of the BBB, and 3) Potential tools that if generated could greatly aid in our understanding of the BBB.
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