期刊
PSYCHOPHARMACOLOGY
卷 235, 期 6, 页码 1727-1743出版社
SPRINGER
DOI: 10.1007/s00213-018-4882-z
关键词
Alcohol; Addiction; Signaling; Translation; Medication Development; Fyn; mTOR; BDNF; GDNF
资金
- National Institute of Alcohol Abuse and Alcoholism [P50AA017072, U01AA023489, R37AA01684]
In recent years, research has identified the molecular and neural substrates underlying the transition of moderate social consumption of alcohol to the characteristic alcohol use disorder (AUD) phenotypes including excessive and compulsive alcohol use which we define in the review as the GO signaling pathways. In addition, growing evidence points to the existence of molecular mechanisms that keep alcohol consumption in check and that confer resilience for the development of AUD which we define herein as the STOP signaling pathways. In this review, we focus on examples of the GO and the STOP intracellular signaling pathways and discuss our current knowledge of how manipulations of these pathways may be used for the treatment of AUD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据