期刊
PSYCHONEUROENDOCRINOLOGY
卷 94, 期 -, 页码 17-24出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2018.05.006
关键词
Stressful life events; White blood cells; Neutrophils; Neutrophil/lymphocyte ratio; Hair cortisol concentration; Cortisol; Glucocorticoids; Disease
资金
- TU Dresden (Support the Best programme, TUD Institutional Strategy, Excellence Initiative)
A plethora of cross-sectional studies suggest that psychological stress resulting from experiencing stressful life events (SLE) can result in an altered immune response. Potential maladaptive immune changes may outlast the event and affect the organism long after stress cessation. As a consequence, an increased vulnerability for immune-mediated pathologies (e.g. arthritis, diabetes) may develop over the life span. The objective of the present study was to monitor the longitudinal kinetics of peripheral white blood cells (WBCs; neutrophils, lymphocytes, and monocytes) in response to SLE. Here we present blood, hair, and behavioural measures obtained in the Dresden Burnout Study, at first visit (T1; N = 446) and one year later (T2; N = 173). Cumulative impact of SLE was assessed at T1 with the Life Stressor Checklist (LSC-R). Results indicate a significant increase in neutrophils (+2.8% per each 10 LSC-R points) between Tl and T2 in association with reported SLE. The change in neutrophils tended to correlate with the change in hair cortisol (Cohefis f = 0.6). We propose that SLE trigger immunological alterations that persist across time and thereby promote a continuous effect on WBC distribution. Such an effect might advance subclinical inflammatory processes, reduce an individualg immune defence, and promote a link between psychological stress and physical disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据