期刊
NATURE REVIEWS CANCER
卷 13, 期 2, 页码 111-122出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3418
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资金
- National Health and Medical Research Council of Australia (NHMRC)
- Australian Postgraduate Awards
- Charles and Sylvia Viertel Foundation Senior Medical Research Fellowship
- Australian Research Council
- NHMRC
LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma. These small proteins contain two protein-interacting LIM domains but little additional sequence, and they seem to function by nucleating the formation of new transcriptional complexes and/or by disrupting existing transcriptional complexes to modulate gene expression programmes. Through these activities, the LMO proteins have important cellular roles in processes that are relevant to cancer such as self-renewal, cell cycle regulation and metastasis. These functions highlight the therapeutic potential of targeting these proteins in cancer.
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