期刊
PSYCHIATRY RESEARCH
卷 268, 期 -, 页码 82-86出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2018.06.067
关键词
CXCL1; Deficit Schizophrenia (DS); DNA methylation; Gene expression
类别
资金
- National Natural Science Foundation of China (NSFC) [81371474, 81571314, 31671144, 81701675]
- National Key Research and Development Program [2016YFC1307000]
- Medical key talent projects in Jiangsu Province [ZDRCA2016075]
- six talent peaks projects in Jiangsu Province [2015-WSN-071]
- Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University [2016PN-KFKT-01]
This study detected the differences in gene expression and DNA methylation of CpG sites in CXCL1 gene and further investigated their associations with clinical symptoms in deficit schizophrenia (DS) and non-deficit schizophrenia (NDS). Pyrosequencing and RT-qPCR were separately used to determine DNA methylation and mRNA expression of CXCL1 gene. Both DNA methylation and expression were significantly different among DS, NDS and healthy control (HC) groups. Correlation analysis revealed that CXCL1 gene expression was associated with the negative syndrome in NDS patients, while no association in DS patients was observed. All together, these results suggest that DS may be a specific subgroup of schizophrenia with the characteristic abnormality of peripheral CXCL1 DNA methylation and gene expression.
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