期刊
PSYCHIATRY RESEARCH
卷 260, 期 -, 页码 111-115出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.11.061
关键词
PTSD; IL-6; IL-10; Interleukins
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul [PRONEX-FAPERGS - 08/2009-Pronex 10/0055-0]
To evaluate the serum levels of IL-6 and IL-10 anti-inflammatory interleukins in individuals with post-traumatic stress disorder (PTSD) in a population-based study. This is a paired study nested in a cross-sectional population based study. All individuals who presented PTSD and did not present major depressive disorder, diagnostic by interview-Mini International Neuropsychiatric Interview were selected. From these, 41 healthy controls were matched by sex and age. Serum levels of IL-6 and IL-10 were measured by the ELISA, using commercial kits. The group of individuals with PTSD showed a significant increase in the serum levels of IL-6 and IL-10. Our results suggest that individuals with PTSD may present an activation of the immune system, which may lead to neuroinflammation.
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