期刊
PSYCHIATRY RESEARCH
卷 260, 期 -, 页码 439-442出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.12.010
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资金
- University of Illinois Beckman Institute Cognitive Science Award
We conducted an epigenome-wide association study of Major Depressive Disorder (MDD) in brain-derived DNA using two analytic approaches. DNA methylation data (GSE41826) was used in differential methylation (DM) analyses controlling for age, sex, suicide status, and post-mortem interval; and in weighted gene co-methylation network analyses (WGCNA) in probes mapping to transcription start sites. No probes in the DM analysis survived FDR correction. Nominally significant DM probes were enriched in synaptic function-related genes. WGCNA revealed one module correlated with MDD, enriched in genes associated with mitochondrial function. DM and WGCNA both showed enrichment of genes involved in transcription and DNA binding.
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