期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 67, 期 -, 页码 56-86出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2018.04.006
关键词
Age-related macular degeneration (AMD); High-density lipoprotein cholesterol (HDL-C); Dietary lipids; Circulating lipoproteins; Retinal lipids; Genetics
资金
- Eye-Risk project from the European Union's Horizon 2020 research and innovation programme [634479]
There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.
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