期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 285, 期 1880, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2018.0294
关键词
fragile-X; social dominance; hierarchy; Fmr1; autism-spectrum disorders; gene-environment interactions
资金
- Wellcome Trust [207481/Z/17/Z]
- Erasmus Mundus EXPERTS-SUSTAIN scholarship
- Royal Society
- Patrick Wild Centre (University of Edinburgh)
- Centre for Brain Development and Repair (NCBS, InStem, Bangalore)
Social withdrawal is one phenotypic feature of the monogenic neurodevelopmental disorder fragile-X. Using a 'knockout' rat model of fragile-X, we examined whether deletion of the Fmr1 gene that causes this condition would affect the ability to form and express a social hierarchy as measured in a tube test. Male fragile-X 'knockout' rats living together could successfully form a social dominance hierarchy, but were significantly subordinate to wild-type animals in mixed group cages. Over 10 days of repeated testing, the fragile-X mutant rats gradually showed greater variance and instability of rank during their tube-test encounters. This affected the outcome of future encounters with stranger animals from other cages, with the initial phenotype of wild-type dominance lost to a more complex picture that reflected, regardless of genotype, the prior experience of winning or losing. Our findings offer a novel insight into the complex dynamics of social interactions between laboratory living groups of fragile-X and wild-type rats. Even though this is a monogenic condition, experience has an impact upon future interactions with other animals. Gene/environment interactions should therefore be considered in the development of therapeutics.
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