期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 6, 页码 E1194-E1203出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1714948115
关键词
autoimmunity; blood-brain barrier; experimental autoimmune encephalomyelitis; interleukin-1 beta; multiple sclerosis
资金
- Multiple Sclerosis Society of Canada (MSSC)
- Fonds de recherche du Quebec en Sante
- MSSC
Molecular interventions that limit pathogenic CNS inflammation are used to treat autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1 beta-knockout mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Here, we show that interfering with the IL-1 beta/IL-1R1 axis severely impairs the transmigration of myeloid cells across central nervous system (CNS) endothelial cells (ECs). Notably, we report that IL-1 beta expression by inflammatory CCR2(hi) monocytes favors their entry into the spinal cord before EAE onset. Following activation with IL-1 beta, CNS ECs release GM-CSF, which in turn converts monocytes into antigen-presenting cells (APCs). Accordingly, spinal cord-infiltrated monocyte-derived APCs are associated with dividing CD4(+) T cells. Factors released from the interaction between IL-1 beta-competent myeloid cells and CD4(+) T cells are highly toxic to neurons. Together, our results suggest that IL-1 beta signaling is an entry point for targeting both the initiation and exacerbation of neuroinflammation.
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