期刊
INFECTION AND CHEMOTHERAPY
卷 45, 期 1, 页码 44-50出版社
KOREAN SOC CHEMOTHERAPY
DOI: 10.3947/ic.2013.45.1.44
关键词
Tuberculosis; ELISPOT; Indeterminate response
资金
- Basic Science Research Program through the National Research Foundation - Ministry of Education, Science and Technology [2010-0005898]
- National Research Foundation of Korea [2010-0005898] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background: The two interferon-gamma release assays such as QuantiFERON-TB Gold / In-Tube (QFT-TB) and T-SPOT. TB - are useful tools for the rapid diagnosis of tuberculosis (TB) but can yield indeterminate test results (ITRs). While some studies have identified risk factors for ITRs in the QFT-TB test, there have been few such studies for the T-SPOT. TB test. The aim of this study was to investigate the risk factors associated with ITRs in the T-SPOT. TB test. Materials and Methods: From April 2008 to August 2010, all patients with suspected extrapulmonary tuberculosis (E-TB) were enrolled in a tertiary hospital in Korea. ITR was defined as < 20 spots in the positive control well or > 10 spots in the negative control well. Results: Out of a total of 368 patients, 32 (8.7%, 95% CI, 6.0% to 11.7%) had ITRs in their T-SPOT. TB tests. The ITRs were due to a low mitogen response in 13 (40.6%) patients and to a high nil response in the other 19 (59.4%) patients. Statistical analysis revealed that old age, underlying diseases, immunosuppressive treatment, lymphopenia, and clinical manifestations of E-TB were not significantly associated with ITRs. Conclusions: Indeterminate results in the T-SPOT. TB test are not affected by age, underlying disease, immunosuppressive treatment, lymphopenia, or clinical manifestations of E-TB, which are known risk factors for indeterminate results in the QFT-TB test.
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