期刊
PHOTOACOUSTICS
卷 1, 期 1, 页码 3-8出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.pacs.2012.11.001
关键词
Myocardial infarction; Optical imaging; Optoacoustic imaging
类别
资金
- Kommission fur Klinische Forschung der TU Munchen
- Deutsche Forschungsgemeinschaft (DFG - German Research Foundation) [SFB 824]
- European Research Council (ERC)
Objectives: To investigate the feasibility of a high resolution optical imaging strategy for myocardial infarction. Background: Near-infrared approaches to imaging cardiovascular disease enable visualization of disease-associated biological processes in vivo. However, even at the scale of small animals, the strong scattering of light prevents high resolution imaging after the first 1-2 mm of tissue, leading to degraded signal localization. Methods: Multispectral optoacoustic tomography (MSOT) was used to non-invasively image myocardial infarction (MI) in a murine model of coronary artery ligation at resolutions not possible with current deep-tissue optical imaging methods. Post-MI imaging was based on resolving the spectral absorption signature of a dendritic polyglycerol sulfate-based (dPGS) near-infrared imaging agent targeted to P-and L-selectin. Results: In vivo imaging succeeded in detection of the agent in the injured myocardium after intravenous injection. The high anatomic resolution (< 200 mm) achieved by the described method allowed signals originating in the infarcted heart to be distinguished from uptake in adjacent regions. Histological analysis found dPGS signal in infarcted areas, originating from leukocytes and endothelial cells. Conclusions: MSOT imaging of myocardial infarction provides non-invasive visualization of optical contrast with a high spatial resolution that is not degraded by the scattering of light. (C) 2012 Elsevier GmbH. Open access under CC BY-NC-ND license.
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