期刊
NATURE REVIEWS IMMUNOLOGY
卷 13, 期 3, 页码 199-206出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3398
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资金
- US National Institutes of Health (NIH)/US National Institute of Allergy and Infectious Diseases (NIAID) through the New England Regional Center of Excellence (NERCE) [U54 AI057159]
- Ligue Nationale Contre le Cancer
- INSERM
- Fondation Infectiopole Sud
- Fondation ARC pour la Recherche sur le Cancer [ARC SFI 20111203659, ARC SFI 20121205382]
- NIH/NIAID
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.
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