期刊
POWDER TECHNOLOGY
卷 334, 期 -, 页码 65-75出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.powtec.2018.04.051
关键词
Discrete element method; Dry powder inhaler; Carrier with drug; Velocity; Rotation; Drug dispersion
资金
- COST (European Cooperation in Science and Technology) [MP1404 SimInhale]
- COST (European Cooperation in Science and Technology)
- STSM (Short Term Scientific Mission) at the MPS laboratory, Institute of Process Engineering, Otto-von-Guericke University Magdeburg, Halle (Saale), Germany
In this work, the Discrete Element Method (DEM) is used to simulate the dispersion process of Active Pharmaceutical Ingredients (API) after a wall collision in dry powders inhaler used for lung delivery. Any fluid dynamic effects are neglected in this analysis at the moment A three-dimensional model is implemented with one carrier particle (diameter 100 mu m) and 882 drug particles (diameter 5 mu m). The effect of the impact velocity (varied between 1 and 20 m s(-1)), angle of impact (between 5 degrees and 90 degrees) and the carrier rotation (+/- 100,000 rad s(-1)) are investigated for both elastic and sticky walls. The dispersion process shows a preferential area of drug detachment located in the southern hemisphere of the carrier. The angle of impact with the highest dispersion is 90 degrees for the velocities over 9 m s(-1) and between 30 degrees and 45 degrees for lower velocities. The rotation of the carrier before the impact, on the other hand, for velocities higher than 7 m s(-1), plays a little role on the dispersion performance. The DEM results are finally distilled into a simplified analytic model that could be introduced as a sub-scale model in Euler/Lagrange CFD calculations linking fluid dynamics with the detachment probability of APIs in the inhaler. (C) 2017 The Authors. Published by Elsevier B.V.
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