期刊
POSTGRADUATE MEDICINE
卷 130, 期 3, 页码 308-316出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00325481.2018.1442090
关键词
Electronic medical records; heart failure with reduced ejection fraction; patient characteristics; PARADIGM-HF; sacubitril/valsartan
资金
- Novartis Pharma AG
Objectives: This study aimed to provide early insights into sacubitril/valsartan (sac/val) prescription patterns and the demographic and clinical characteristics of patients prescribed sac/val in primary care and cardiology settings in Germany. Methods: The study used electronic medical records from the German IMS (R) Disease Analyzer database. Patients with 1 prescription for sac/val during 1 January-31 December 2016 (n = 1643) were identified and followed up for <= 12 months from first prescription. Patients with >= 1 heart failure (HF) diagnosis during the study period, 1 additional HF diagnosis in the full history of the database, and >= 1 prescription for an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and beta-blocker during the study period, without a prescription for sac/val (n = 25,264), were included as a reference cohort. Changes in clinical parameters in the 12 months before and after sac/val initiation were investigated and compared with those from the PARADIGM-HF study. Results: The characteristics of patients prescribed sac/val more closely resembled those of patients enrolled in PARADIGM-HF (e.g. younger age, higher proportion of men than women, lower systolic blood pressure) than patients in the reference cohort. Most patients were initiated on the lowest dose of sac/val irrespective of clinical setting. Significant decreases (p < 0.001) in NT-proBNP and glycated haemoglobin levels were observed following sac/val initiation. Conclusions: Patients prescribed sac/val had similar baseline demographics and clinical characteristics to those from PARADIGM-HF, and most patients were initiated on the lowest dose. Changes in clinical parameters before and after initiation mirrored findings from the PARADIGM-HF study.
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