期刊
CHILD DEVELOPMENT
卷 84, 期 1, 页码 89-103出版社
WILEY
DOI: 10.1111/j.1467-8624.2012.01759.x
关键词
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资金
- NIMH NIH HHS [R21MH073393, R21 MH073393, R21 MH073393-02] Funding Source: Medline
- Autism Speaks [AS2381] Funding Source: Medline
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism. Emphasis is placed on the need to study defined ASD phenotypes as well as to integrate large-scale omics data in order to develop a systems-level perspective of ASD, which in turn is necessary to allow predictions regarding responses to specific perturbations and interventions.
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