期刊
POLYMER CHEMISTRY
卷 9, 期 2, 页码 169-177出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7py01739a
关键词
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资金
- Shanghai Leading Academic Discipline Project [B502]
- Shanghai Key Laboratory Project [08DZ2230500]
- National Natural Science Foundation of China [21303050, 31471659, 21636003]
- Fundamental Research Funds for the Central Universities [222201514327]
- State Key Laboratory of Functional Materials for Informatics Open Project [SKL201306]
- Shanghai Pujiang Program [13PJ1401700]
- Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)
Nanoparticles are appealing drug delivery systems since they promise prolonged circulation time and predictable release behaviors. The current work reports a novel hyperbranched amphiphilic block copolymer synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery. PEG2000-Br was applied as a macroinitiator to initiate acid-cleavable divinyl (ACD) monomers linked by acetal groups, formulating the hydrophilic (PEG) and hydrophobic (ACD) segments. The polymer appeared to self-assemble into micelles with diameters in the range of 70-100 nm, and was examined for the controlled release of doxorubicin (DOX). Results showed that DOX-loaded micelles (similar to 90 nm) could achieve drug loading as high as 8.2 wt%, with interesting pH-dependent release behaviors. Studies with flow cytometry (FCM) and confocal laser scanning microscopy (CLSM) showed that DOX-loaded micelles exhibited a high cellular uptake performance by HeLa cells, which indicated promising antitumor efficacy for such a drug delivery system. Additionally, such DOX-loaded micelles exhibited remarkable cytotoxicity against HeLa cells in a dose-and time-dependent manner due to the enhanced cell uptake behavior of micelles. These results indicated that the polymeric micelles might be used as a promising candidate for a pH-responsive drug delivery for cancer therapy.
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