[Cu3(BTC)2]: A metal-organic framework as an environment-friendly and economically catalyst for the synthesis of tacrine analogues by Friedlander reaction under conventional and ultrasound irradiation

Using a green and simple route with ultrasound illumination, atmospheric pressure and room temperature, for synthesizing tacrine analogues in the presence of [Cu-3(BTC)(2)] as an environment-friendly and economically catalyst was considered. [Cu-3(BTC)(2)] is one of the heterogeneous catalysts on hand capable of being employed, in the Friedlander reaction, whenever 5-amino-4-cyano-2-phenyl-1,3-oxazole and appropriately substituted carbonyl derivatives under conventional and ultrasonic irradiation. The results of this study indicate that the active sites in the [Cu-3(BTC)(2)] for synthesis of cyclohepta[b]oxazolo[4,5-e] pyridine are mainly copper atoms and the role of Brbnsted acid organic ligand in the MOF is negligible. These procedures were properly arranged in order to provide the utmost yields in a short while. The crystal stability in the process of catalysis was investigated by various techniques such as XRD, BET and ICP that demonstrate excellent stability in reaction conditions. (C) 2018 Elsevier Ltd. All rights reserved.