期刊
POLYCYCLIC AROMATIC COMPOUNDS
卷 40, 期 3, 页码 585-593出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2018.1464038
关键词
Acetoacetanilide; cyclohexenones; one-pot reaction; tetramethyl; ammonium hydroxide
资金
- Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran [4.5830]
The direct three-component reaction of 2-acetylnaphthalene, benzaldehydes, and acetoacetanilide to produce a novel series of cyclohexenone derivatives has been carried out over tetramethylammonium hydroxide pentahydrate in ethanol at 70 degrees C. One-pot reaction, high efficiency, short reaction time, and easy purification of products by simple recrystallization are some of the considerable advantages of this procedure. The produced cyclohexenone derivatives were screened for their antibacterial activity againstEscherichia coli,Staphylococcus aureus,andPseudomonas aeruginosa. The results showed that the cyclohexenones 4g, 4i, and 4j had good antibacterial activity towardEscherichia coliand the cyclohexenones 4j and 4k had good antibacterial activity againstStaphylococcus aureus.
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