期刊
WORLD JOURNAL OF HEPATOLOGY
卷 5, 期 3, 页码 109-113出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4254/wjh.v5.i3.109
关键词
Alanine aminotransferase; Aspartate aminotransferase; Total cholesterol; Gamma-glutamyl transpeptidase; Non alcoholic fatty liver disease; Silymarin; Steato test; Hepatorenal ultrasonographic index; Fasting glucose level; High density lipoprotein and low density lipoprotein cholesterol; Homeostatic model assessment insulin resistance test
AIM: This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD). METHODS: In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture (hepatorenal ratio brightness) was also defined at same time. These evaluations were repeated after 6 mo of treatment. RESULTS: Serum levels of some metabolic and anti-inflammatory data nonsignificantly lowered after 6 mo of silymarin. On the contrary, Steato test, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase were significantly (P < 0.001) reduced. Instead, the AST/ALT ratio unchanged. Finally, the hepatorenal brightness ratio, as an index of hepatic steatosis, significantly (P < 0.05) dropped. CONCLUSION: The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. Some parameters indicative of early stage of atherosclerosis were also lowered. (C) 2013 Baishideng. All rights reserved.
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