期刊
PET CLINICS
卷 8, 期 2, 页码 201-+出版社
ELSEVIER INC
DOI: 10.1016/j.cpet.2012.09.002
关键词
PET; PET parametric response maps; Glioblastoma; GBM; Brain tumors; Imaging; Response; Biomarker
资金
- UCLA Institute for Molecular Medicine Seed Grant
- UCLA Radiology Exploratory Research Grant
- University of California Cancer Research Coordinating Committee Grant
- ACRIN Young Investigator Initiative Grant
- Art of the Brain
- Ziering Family Foundation
- Singleton Family Foundation
- Clarence Klein Fund for Neuro-Oncology
PET parametric response maps (PRMs) are a provocative new molecular imaging technique for quantifying brain tumor response to therapy in individual patients. By aligning sequential PET scans over time using anatomic MR imaging information, the voxel-wise change in radiotracer uptake can be quantified and visualized. PET PRMs can be performed before and after a particular therapy to test whether the tumor is responding favorably, or performed relative to a distant time point to monitor changes through the course of a treatment. This article focuses on many of the technical details involved in generating, visualizing, and quantifying PET PRMs, and practical applications and example case studies.
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