4.6 Article

Dynamic cortical participation during bilateral, cyclical ankle movements: Effects of Parkinson's disease

期刊

PLOS ONE
卷 13, 期 4, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0196177

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资金

  1. Toronto Rehabilitation Institute Student Scholarship from the University of Toronto
  2. CREATE Academic Rehabilitation Engineering Fellowship from the Natural Sciences and Engineering Research Council of Canada
  3. Canadian Institutes of Health Research [MOP 15128, OMH131582]
  4. Toronto Rehabilitation Institute University Health Network
  5. Natural Sciences and Engineering Research Council [249669]

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Parkinson's disease (PD) is known to increase asymmetry and variability of bilateral movements. However, the mechanisms of such abnormalities are not fully understood. Here, we aimed to investigate whether kinematic abnormalities are related to cortical participation during bilateral, cyclical ankle movements, which required i) maintenance of a specific frequency and ii) bilateral coordination of the lower limbs in an anti-phasic manner. We analyzed electroencephalographic and electromyographic signals from nine men with PD and nine aged-matched healthy men while they sat and cyclically dorsi- and plantarflexed their feet. This movement was performed at a similar cadence to normal walking under two conditions: i) self-paced and ii) externally paced by a metronome. Participants with PD exhibited reduced range of motion and more variable bilateral coordination. However, participants with and without PD did not differ in the magnitude of corticomuscular coherence between the midline cortical areas and tibialis anterior and medial gastrocnemius muscles. This finding suggests that either the kinematic abnormalities were related to processes outside linear corticomuscular communication or PD-related changes in neural correlates maintained corticomuscular communication but not motor performance.

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