期刊
THERAPEUTIC DELIVERY
卷 4, 期 4, 页码 463-470出版社
FUTURE SCI LTD
DOI: 10.4155/TDE.13.11
关键词
Process analytical technology; Quality by design; Granulation; Placebo formulation; In-line; Off-line; At-line
资金
- A*STAR SERC [102 161 0049 (R-148-000-157-305)]
Continuous processing and production in pharmaceutical manufacturing has received increased attention in recent years mainly due to the industries' pressing needs for more efficient, cost-effective processes and production, as well as regulatory facilitation. To achieve optimum product quality, the traditional trial-and-error method for the optimization of different process and formulation parameters is expensive and time consuming. Real-time evaluation and the control of product quality using an online process analyzer in continuous processing can provide high-quality production with very high-throughput at low unit cost. This review focuses on continuous processing and the application of different real-time monitoring tools used in the pharmaceutical industry for continuous processing from powder to tablets.
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