期刊
PLOS ONE
卷 13, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0195549
关键词
-
资金
- National Institutes of Health [MH077650, AT003480, P01-AG024831, AG13308, P50 AG 16570, MH/AG58156, AG10123, M01-RR00865]
- Department of Energy [DE-FC03-87-ER60615]
- McLoughlin Gift Fund for Cognitive Health
- Larry L. Hillblom Foundation
- Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research
- Ahmanson Foundation
- Lovelace Foundation
- Sence Foundation
- UCLA Claude Pepper Older Americans Independence Center - National Institute on Aging [5P30AG028748]
- AFAR
- John A. Hartford Foundation
- Centers of Excellence National Program, National Institutes of Health/National Center for Advancing Translational Science (NCATS) University of California Los Angeles Center for Translational Science Investigation [UL1TR000124]
Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily studied memory-critical region within the MTL. However, research on associations between sedentary behavior and MTL subregion integrity is limited. Here we explore associations between thickness of the MTL and its subregions (namely CA1, CA23DG, fusiform gyrus, subiculum, parahippocampal, perirhinal and entorhinal cortex,), physical activity, and sedentary behavior. We assessed 35 non-demented middle-aged and older adults (25 women, 10 men; 45-75 years) using the International Physical Activity Questionnaire for older adults, which quantifies physical activity levels in MET-equivalent units and asks about the average number of hours spent sitting per day. All participants had high resolution MRI scans performed on a Siemens Allegra 3T MRI scanner, which allows for detailed investigation of the MTL. Controlling for age, total MTL thickness correlated inversely with hours of sitting/day (r = -0.37, p = 0.03). In MTL subregion analysis, parahippocampal (r = -0.45, p = 0.007), entorhinal (r = -0.33, p = 0.05) cortical and subiculum (r = -0.36, p = .04) thicknesses correlated inversely with hours of sitting/day. No significant correlations were observed between physical activity levels and MTL thickness. Though preliminary, our results suggest that more sedentary non-demented individuals have less MTL thickness. Future studies should include longitudinal analyses and explore mechanisms, as well as the efficacy of decreasing sedentary behaviors to reverse this association.
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