期刊
PLATELETS
卷 30, 期 2, 页码 199-205出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/09537104.2017.1392499
关键词
Acute kidney injury; apoptosis; platelet; sepsis; ticagrelor
资金
- National Natural Science Foundation of China [81670067]
Platelets are traditionally considered to be essential components of primary hemostasis. Recent investigations have revealed that platelets can be activated in patients with sepsis and are implicated in the development of sepsis and sepsis-induced-acute kidney injury (SAKI). In the present study, ticagrelor was used to induce a mouse model of SAKI by cecal ligation and puncture. It was found that ticagrelor could inhibit platelet activity, decrease the levels of interleukin-1 beta and serum creatinine, reduce infiltration of neutrophils in renal tissue, and attenuate cell apoptosis in the kidney. The results suggested that ticagrelor could protect renal function by inhibiting inflammation, recruitment of neutrophils into the kidney, and cell apoptosis in renal tissue. Thus, the findings might provide new strategies for preventing SAKI.
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