期刊
WORLD JOURNAL OF DIABETES
卷 4, 期 2, 页码 27-30出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v4.i2.27
关键词
Tubular cells; Renal; Apoptosis; Diabetes
资金
- American Heart Association
Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Hyperglycemia and high glucose in vitro also lead to apoptosis, a form of programmed cell death. High glucose similar to those seen with hyperglycemia in people with diabetes mellitus, lead to accelerated apoptosis, a form of programmed cell death characterized by cell shrinkage, chromatin condensation and DNA fragmentation, in variety of cell types, including renal proximal tubular epithelial cells. (C) 2013 Baishideng. All rights reserved.
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