期刊
PLANT CELL AND ENVIRONMENT
卷 41, 期 4, 页码 837-849出版社
WILEY
DOI: 10.1111/pce.13148
关键词
Arabidopsis thaliana; autophagy; environmental stress; sphingolipids
资金
- National Natural Science Foundation of China [31570255, 31771357]
- Foundation of Guangzhou Science and Technology Project [201504010021]
- Natural Science Foundation of Guangdong Province [2015A030313156]
- Fundamental Research Funds for the Central Universities [16lgjc74]
- China Postdoctoral Science Foundation [2016M592575]
Sphingolipids, a class of bioactive lipids found in cell membranes, can modulate the biophysical properties of the membranes and play a critical role in signal transduction. Sphingolipids are involved in autophagy in humans and yeast, but their role in autophagy in plants is not well understood. In this study, we reported that the AtACER, an alkaline ceramidase that hydrolyses ceramide to long-chain base (LCB), functions in autophagy process in Arabidopsis. Our empirical data showed that the loss of AtACER inhibited autophagy, and its overexpression promoted autophagy under nutrient, salinity, and oxidative stresses. Interestingly, nitrogen deprivation significantly affected the sphingolipid's profile in Arabidopsis thaliana, especially the LCBs. Furthermore, the exogenous application of LCBs also induced autophagy. Our findings revealed a novel function of AtACER, where it was found to involve in the autophagy process, thus, playing a crucial role in the maintenance of a dynamic loop between sphingolipids and autophagy for cellular homeostasis under various environmental stresses.
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